Rapid Antidepressant Action of Ketamine in Psychiatric Patients with Suicidality - a Case Series
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چکیده
Ketamine, a non-competitive NMDA receptor antagonist with rapid antidepressant action, is a novel approach in modulating glutamate receptors for management of treatment-resistant major depressive disorder. It clinically engenders meaningful advances in depression therapeutics. This case series highlights the role of low dose intravenous ketamine infusion i.e., 0.5 mg/kg dissolved in 100 ml normal saline and given over a period of 40 minutes in patients of depression who were contemplating suicide.
منابع مشابه
Use of ketamine in acute cases of suicidality.
Ketamine is an N-methyl-D- aspartate antagonist with rapid antidepressant effects. Research shows that ketamine has a fast onset of reduction in depressive symptoms and shows sustained remission of suicidal ideation in some patients. This article provides a brief review of the literature on the use of ketamine for depression and in acute cases of suicidality. The authors conclude that, while fu...
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Major depressive disorder is a common, recurrent and disabling psychiatric disorder associated with significant morbidity and mortality. For half a century, the field of neuro psychopharmacology of depression has been dominated by the monoaminergic hypothesis, especially regarding the development of antidepressant drugs. However, the mono aminergic antidepressants have significant limitations: ...
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تاریخ انتشار 2014